Background & Objective: Liver disease in pregnancy can have serious consequences. We studied the profile of liver disease in pregnant women and its correlation with outcome of pregnancy during the hospital stay in a tertiary care hospital.
Methods: Pregnantwomen with liver disease admitted in the departments of Medicine, Gastroenterology and Obstetrics & Gynaecology between January 2011 and June 2012 in a tertiary care hospital of North India were evaluated for various parameters.
Results: Out of 2663 pregnant women, 92 patients (3.45%) were diagnosed to have liver disease. Acute viral hepatitis (AVH) was found in 42 (45.6%) and pregnancy specific liver disease in 39 (42.4%) patients. Hypertensive disorder of pregnancy including HELLP Syndrome (Hemolysis, Elevated liver enzymes, Low platelet count) was seen in 27 patients (29.3%). Four patients had leptospirosis and hepatitis E co-infection. Overallmaternal and perinatal mortality was 7.6% (7/92) and 25% (23/92) respectively.
Interpretation and Conclusion: Acute viral hepatitis (45.6%) was the most common cause of liver disease in pregnancy in our study.