Journal of Gastrointestinal Infections

Register      Login

VOLUME 4 , ISSUE 1 ( 2014 ) > List of Articles

REVIEW ARTICLE

Listeriosis in Pregnancy: A Deadly and Under Diagnosed Gastrointestinal Infection

Amandeep K Anand, Sandeep Dogra

Keywords : Listeriosis, Listeria monocytogenes, pregnancy, neonates

Citation Information : Anand AK, Dogra S. Listeriosis in Pregnancy: A Deadly and Under Diagnosed Gastrointestinal Infection. J Gastrointest Infect 2014; 4 (1):12-15.

DOI: 10.5005/jogi-4-1-12

License: CC BY-SA 4.0

Published Online: 01-10-2015

Copyright Statement:  Copyright © 2014; The Author(s).


Abstract

Human listeriosis, a dreaded gastrointestinal disease of the West has surfaced in the last two decades in India, and there have been a series of reports on sporadic cases. The causative organism, Listeria monocytogenes is an intracellular Gram-positive bacillus ubiquitous in soil and vegetation. It is responsible for cases and outbreaks of febrile gastrointestinal disease in otherwise healthy people and invasive listeriosis, which usually affects pregnant women, newborns & the elderly. Immunocompromised individuals and pregnant women have been identified as major risk factors for listeriosis. It is about 20 times more common in pregnant women than in the general population. It causes mild illness in mothers, but can be devastating to the fetus, in some cases leading to severe disease or fetal death. It may cause abortion, premature labour, fetal death or neonatal morbidity in the form of septicemia and meningitis. This review is an attempt to sensitize clinicians especially obstetricians to include listeriosis as a differential diagnosis in patients with high suspicion and institute early antimicrobial therapy. Also there is need to press upon proper counseling of pregnant women for preventive measures against this deadly infection.


PDF Share
  1. Murray EGD, Webb RA, Swann MBR. A disease of rabbits characterized by a large mononuclear leucocytosis, caused by a hitherto undescribed bacillus Bacterium monocytogenes (n.Sp.). J Path Bacteriol 1926;29(4):407–39.
  2. Goulet V, Hebert M, Hedberg C, Laurent E, Vaillant V, De Valk H, et al. Incidence of listeriosis and related mortality among groups at risk of acquiring listeriosis. Clin Infect Dis 2012 1;54(5):652-60.
  3. Scallan E, Hoekstra RM, Angulo FJ, Tauxe RV, Widdowson MA, Roy SL, et al. Foodborne illness acquired in the United States--major pathogens. Emerg Infect Dis 2011;17(1):7-15.
  4. Janakiraman V. Listeriosis in pregnancy: diagnosis, treatment, and prevention. Rev Obstet Gynecol 2008;1(4):179-85.
  5. Centers for Disease Control and Prevention. Multistate outbreak of listeriosis associated with Jensen Farms cantaloupe-United States, August-September 2011. MMWR Morbidity and mortality weekly report 2011;60(39):1357-8.
  6. Gupta V, Gautam V, Mehta N, Kumari I, Joshi RM. Listeriosis in second trimester of pregnancy: case report from India. J Infect Dis 2003;56(2):60-1.
  7. Srivastava S, Sen MR, Kumar A, Anupurba S. Neonatal listeriosis. Indian J Pediatr 2005;72(12):1059-60.
  8. Janakiraman V. Listeriosis in pregnancy: Diagnosis, Treatment and Prevention. Rev Obstet Gynecol 2008;1(4):179-85.
  9. Southwick FS, Purich DL. Intracellular pathogenesis of listeriosis. New Engl J Med 1996;334(12):770-6.
  10. Almeida G, Morvan A, Magalhães R, Santos I, Hogg T, Leclercq A, et al. Distribution and characterization of Listeria monocytogenes clinical isolates in Portugal, 1994-2007. Eur J Clin Microbiol Infect Dis 2010;29(10):1219-27.
  11. Doyle ME. Virulence characteristics of Listeria monocytogenes. Fri Briefings 2001; Food Research Institute, University of Wisconsin, pp. 1–13.
  12. Scheule B. Food safety education: health professionals' knowledge and assessment of WIC client needs. J Am Diet Assoc 2004;104(5):799–803.
  13. Cossart P. Molecular and cellular basis of the infection by Listeria monocytogenes: an overview. Int J Med Microbiol 2001;291:401–9.
  14. Lecuit M. Human listeriosis and animal models. Microbes Infect 2007:9(10):1216–25.
  15. Vázquez-Boland JA, Kuhn M, Berche P, Chakraborty T, Domínguez-Bernal G, Goebel W, et al. Listeria pathogenesis and molecular virulence determinants. Clin Microbiol Rev 2001;14(3):584-640.
  16. Pizarro-Cerdá J, Cossart P. Subversion of cellular functions by Listeria monocytogenes. J Pathol 2006;208(2):215-23.
  17. Freitag NE, Port GC, Miner MD. Listeria monocytogenes— from saprophyte to intracellular pathogen. Nat Rev Microbiol 2009;7(9):623–8.
  18. Mylonakis E, Paliou M, Hohmann EL, Calderwood SB, Wing EJ. Listeriosis during pregnancy: a case series and review of 222 cases. Medicine 2002;81(4):260-9.
  19. Lamont RF, Sobel J, Mazaki-Tovi S, Kusanovic JP, Vaisbuch E, Kim SK, et al. Listeriosis in human pregnancy: a systematic review. J Perinat Med 2011;39(3):227-36.
  20. DiMaio H. Listeria infection in women. Primary Care Update for Ob/Gyns 2000;7(1):40–5.
  21. Mascola L, Ewert DP, Eller A. Listeriosis: a previously unreported medical complication in women with multiple gestations. Am J Obstet Gynecol 1994;170:1328.
  22. Sisó C, Goncé A, Bosch J, Salvia MD, Hernández S, Figueras F. Listeriosis in pregnancy: a secular trend in a tertiary referral hospital in Barcelona. Eur J Clin Microbiol Infect Dis 2012;31(9):2125-32.
  23. Jackson KA, Iwamoto M, Swerdlow D. Pregnancy-associated listeriosis. Epidemiol Infect 2010;138(10):1503–9.
  24. Schwab JP, Edelweiss MIA. Immunohistochemical identification of Listeria monocytogenes in formalin-fixed and paraffin-embedded placentas. Revista Brasileira de Ginecologia e Obstetrícia 2003;25:501–5.
  25. Relier J P. Perinatal and neonatal infections: listeriosis. J Antimicrob Chemother 1979;5:51–7.
  26. McLauchlin J. Human listeriosis in Britain, 1967–85, a summary of 722 cases: 1. Listeriosis during pregnancy and in the newborn. Epidemiol Infect 1990;104(2):181-89.
  27. Linnan MJ, Mascola L, Lou XD, Goulet V, May S, Salminen C et al. Epidemic listeriosis associated with Mexican-style cheese. N Engl J Med 1988;29;319(13):823-8.
  28. Hofer E, do Nascimento RS, de Oliveira MA. Listeria monocytogenes Meningitis. Case reports in patients of Federal District. Rev Soc Bras Med Trop 1998;31(2):173-7.
  29. Schlech WF. Foodborne listeriosis. Clin Infect Dis 2000; 31(3):770–5.
  30. Posfay-Barbe KM., Wald ER. Listeriosis. Semin Fetal Neonatal Med. 2009;14(4): 228–33.
  31. DeWaal S, Birkett D, Enga Z. Unexpected consequences: miscarriage and birth defects from tainted food. Center for Science in the Public Interest Washington, DC, USA, 2000.
  32. Buzby, Jean C. Children and microbial foodborne illness. Food Review 2001;24:32–7.
  33. Laciar LA, Hasuoka R P, Correa S M, Miranda AM, Centorbi ONP. Symptomatic hydrocephalus in a newborn infected with Listeria monocytogenes. Braz J Microbiol 2000;31(1):9–11.
  34. Bortolussi R. Listeria monocytogenes infections in neonates. Seminars in Pediatric Infectious Diseases 1999;10(2):111–8.
  35. Temple ME, Nahata MC. Treatment of listeriosis. Ann Pharmacother 2000;34(5):656–61.
  36. Morvan A, Moubareck C, Leclercq A, Hervé-Bazin M, Bremont S, Lecuit M, et al. Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France. Antimicrob Agents Chemother 2010;54(6):2728–31.
  37. Achieving continuous improvement in reductions in foodborne listeriosis—a risk-based approach. J Food Prot 2005;68(9): 1932–94.
  38. Wong S, Marcus R, Hawkins M, Shallow S, McCombs KG, Swanson E, et al. Physicians as food-safety educators: a practices and perceptions survey. Clin Infect Dis 2004; 38(3):212–8. 15
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.