Journal of Gastrointestinal Infections

Register      Login

VOLUME 4 , ISSUE 1 ( 2014 ) > List of Articles


Genotypic Distribution and Associated Disease Pattern of Hepatitis C Virus in Northern India

Omesh Goyal, Ajit Sood

Keywords : Hepatitis C virus, genotype

Citation Information : Goyal O, Sood A. Genotypic Distribution and Associated Disease Pattern of Hepatitis C Virus in Northern India. J Gastrointest Infect 2014; 4 (1):40-43.

DOI: 10.5005/jogi-4-1-40

License: CC BY-SA 4.0

Published Online: 01-10-2015

Copyright Statement:  Copyright © 2014; The Author(s).


Background & Objectives: Hepatitis C virus (HCV) genotype has emerged as an independent factor for disease progression, and it also influences the duration and response to anti-viral therapy. HCV genotypic distribution varies geographically. This retrospective analysis was performed to study the genotypic distribution of chronic hepatitis C and its effect on disease presentation in northern Indian population. Material and Methods: All treatment eligible patients with HCV infection presenting to the gastroenterology outpatient department at our institute between January 2004 and December 2013 were enrolled. Results: A total of 1202 patients with hepatitis C virus infection were included. The mean age of patients was 41.5 ±11.8 years and 70% were males. The mean ALTlevel was 106.4 ± 85.4 IU/Land high viral load was present in 50.7%. Evidence of cirrhosis was present in 22.5%. The most common genotype was genotype 3 (80.1%), followed by genotype 1 (15.4%), genotype 4 (1.4%) and genotype 2 (0.5%). All the clinical and biochemical characteristics in genotype 1 and 3 patients were similar except that a significantly higher proportion of patients with genotype 1 had a high viral load. The percentage of cirrhotic patients among genotype 1 was 25.9% as compared to 22.2% among genotype 3. Interpretation & Conclusion: Genotype 3 is the most prevalent genotype in the HCV infected patients in northern India, followed by genotype 1. There was no significant difference in disease presentation among genotype 1 and 3 patients.

PDF Share
  1. Benvegnù L, Gios M, Boccato S, Alberti A. Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications. Gut. 2004;53(5):744–9.
  2. Hissar SS, Goyal A, Kumar M, Pandey C, Suneetha PV, Sood A, et al. Hepatitis C virus genotype 3 predominates in North and Central India and is associated with significant histopathologic liver disease. J Med Virol 2006;78:452-8.
  3. Trepo C. Genotype and viral load as prognostic indicators in the treatment of hepatitis C. J Viral Hepatitis 2000;7:250–7.
  4. Xavier F, Bukh J. Methods for determining the hepatitis C genotype. Viral Hepatitis Rev 1998; 4:1–19.
  5. Esteban JI, Sauleda S, Quer J. The changing epidemiology of hepatitis C virus infection in Europe. J Hepatol 2008;48:148–62.
  6. Antaki N, Craxi A, Kamal S, Moucari R, Van der Merwe S, Haffar S, et al. The neglected hepatitis C virus genotypes 4, 5 and 6: an international consensus report. Liver Int 2010;30:342–55.
  7. Amrapurkar A, Dhorda M, Kirpalani A, Amarapurkar A, Kankonkar XX. Prevalence of hepatitis C genotypes in Indian patients and their clinical significance. J Assoc Physicians India 2001;49:983–5.
  8. Chowdhury A, Santra A, Chaudhuri S, Dhali GK, Chaudhuri S, Maity SG. Hepatitis C virus infection in the general population: A community-based study in West Bengal, India. Hepatology 2003;37:802–9.
  9. Das BR, Kundu B, Khandapkar R, Sahni S. Geographic distribution of hepatitis C virus genotypes in India. Ind J Path Microbiol 2002;45:323–8.
  10. Sood A, Midha V, Goyal O, Hissar S, Sharma SK, Khanna P. Treatment of chronic hepatitis C with pegylated interferon plus ribavirin in treatment-naïve 'real-life' patients in India. Indian J Gastroenterol 2014;33(4):343-9
  11. Raghuraman S, Shaji RV, Sridharan G, Radhakrishnan S, Chandy G, Ramakrishna BS. Distribution of the different genotypes of HCV among patients attending a tertiary care hospital in south India. J Clin Virol 2003;26:61–9.
  12. Chandra M, Khaja MN, Farees N, Poduri CD, Hussain MM, Aejaz Habib M et al. Prevalence, risk factors and genotype distribution of HCV and HBV infection in the tribal population: A community based study in South India. Trop Gastroenterol 2003;24:193–5.
  13. Gracia-Samaniego J, Soriano V, Castill J, Braco R, Moreno A, Carbo J. Influence of hepatitis C virus genotypes and HIV infection on histological severity of chronic hepatitis C. Am J Gastroenterol 1997;92:1130–4.
  14. De Moliner XX, Pontisso P, De Salvo GL, Cavalletto L, Chemelo L, Alberti A. Serum and liver HCV RNA levels in patients with chronic hepatitis C: Correlation with clinical and histological features. Gut 1998;42:856–60.
  15. Rubbia-Brandt L, Qudri XX, Abid K, Giostra E, Male PJ, Mentha G, et al. Hepatocyte steatosis is a cytopathic effet of hepatitis C virus in genotype 3. J Hepatol 2000;33:106–15.
  16. Malhotra V, Sakhuja P, Gondal R, Sarin SK, Siddhu M, Dutt N. Histological comparison of chronic hepatitis B and C in an Indian population. Trop Gastroenterol 2000;21:20–1.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.