Journal of Gastrointestinal Infections

Register      Login

VOLUME 7 , ISSUE 1 ( 2017 ) > List of Articles

Research News Scan

Databases for Antimicrobial Resistance Genes and Mobile Genetic Elements in Gut Microbiome

Anshul Sood

Keywords : Antimicrobial resistance, Intestinal microbiome mobile element database, Mobile genetic elements, Split read insertion detection.

Citation Information : Sood A. Databases for Antimicrobial Resistance Genes and Mobile Genetic Elements in Gut Microbiome. J Gastrointest Infect 2017; 7 (1):41-42.

DOI: 10.5005/jogi-7-1-41

License: CC BY-SA 4.0

Published Online: 01-11-2015

Copyright Statement:  Copyright © 2017; The Author(s).


The human gut microbiota forms a large reservoir of antimicrobial resistance (AMR) genes. Also a number of these bacteria are endowed with metabolic potentials and added advantages which are often provided by mobile genetic elements (MGE). MGEs carry out extensive horizontal gene transfer (HGT) in gut and are believed to be agents of open source evolution. Regardless of their medical importance and biological significance, MGEs from the gut microbiome have not been methodically characterized. This research news scan highlights the Intestinal microbiome mobile element database (ImmeDB) associated with the collection, classification, and annotation of MGEs from gut microbiome using a novel “deletion-based” Split Read Insertion Detection (SRID) method. The database can help us screen already identified genomes for the validation and detection of new MGEs

PDF Share
  1. Schaik WV. The human gut resistome. Philos Trans R Soc Lond B Biol Sci 2015 June;370(1670):20140087.
  2. Xavier BB, Das AJ, Cochrane G, De Ganck S, Kumar-Singh S, Aarestrup FM, Goossens H, Malhotra-Kumar S. Consolidating and exploring antibiotic resistance gene data resources. J Clin Microbiol 2016 Apr;54(4):851-859.
  3. Frost LS, Leplae R, Summers AO, Toussaint A. Mobile genetic elements: the agents of open source evolution. Nat Rev Microbiol 2005 Sep;3(9):722-732.
  4. Jiang X, Hall AB, Xavier RJ, Alm EJ. Comprehensive analysis of mobile genetic elements in the gut microbiome reveals a phylum-level niche-adaptive gene pool. bioRxiv preprint first posted online Nov. 6, 2017.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.