Journal of Gastrointestinal Infections

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VOLUME 10 , ISSUE 1 ( January-December, 2020 ) > List of Articles


Oral Dysbiosis and the Gut

Sonia Bhonchal Bhardwaj

Citation Information : Bhardwaj SB. Oral Dysbiosis and the Gut. J Gastrointest Infect 2020; 10 (1):26-28.

DOI: 10.5005/jp-journals-10068-3042

License: CC BY-NC 4.0

Published Online: 01-06-2021

Copyright Statement:  Copyright © 2020; The Author(s).


The oral cavity and the gut are distinct organs having specific microbiomes. However, studies in animals and humans have indicated that oral bacteria can overcome the physical and microbial barrier and colonize the gut, especially in the small intestine. The oral microbiome is associated with oral and systemic diseases. The bacteria mainly implicated in causing oral dysbiosis—Porphyromonas gingivalis and Fusobacterium nucleatum—on colonizing the gut alter the intestinal microbiome, creating dysbiosis in the gut microbiome and promoting the immune and inflammatory responses resulting in gastrointestinal diseases. This area of research, although still in its infancy, highlights the need for a coordinated approach to the treatment of periodontitis and development of gastrointestinal disease and also evaluation of emerging microbiome-based therapeutic approaches in the treatment of disease.

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