Background: The goal of prosthodontic rehabilitation entitles preservation of the remaining dentition and a long-term maintenance care, thus ensuring the stability of the dentition and the prosthesis. This becomes crucial in a patient with maxillary acquired defects where the social, behavioral, and the functional changes are involved. Status of the remaining dentition, the size, and extent of the lesion will mainly determine the overall prosthetic treatment plan. Aim: This study aims to elaborate the importance of meticulous treatment planning in the prosthetic rehabilitation of a patient who presented with a maxillary acquired defect. Case report: This clinical report describes the management of a patient with maxillary defect, where the remaining dentition has become further compromised due to inadequate maintenance care, thus resulting in a challenge in the prosthetic rehabilitation. Conclusion: Rehabilitation of an acquired maxillary defect with a compromised dentition, using definitive closed hollow bulb obturator, took care of the different domains of care, giving an improved quality of life to the patient. Clinical significance: Careful treatment planning with an aim to preserve the existing dentition and provide adequate maintenance care is essential for a successful outcome in the prosthetic management of patients with maxillary acquired defects.