Evolution-proof Antibiotics

Anshul Sood

doi:10.5005/jp-journals-10068-0022

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Evolution-proof Antibiotics

Anshul Sood

Keywords : Antimicrobial resistance, Evolution-proof antibiotics, Horizontal gene transfer

Citation Information : Sood A. Evolution-proof Antibiotics. J Gastrointest Infect 2018; 8 (1):51-51.

DOI: 10.5005/jp-journals-10068-0022

License: CC BY-NC 4.0

Published Online: 01-12-2018

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Abstract

Evolving resistance in pathogenic bacteria has compromised the efficacy of current antibiotics. The need of the hour dictates producing antibiotics to which the bacteria cannot produce resistance. Attractive options possible are first, formulating ‘evolution-proof’ antibiotics via mutation or horizontal gene transfer which bacteria cannot resist and secondly by producing compounds to which resistance may develop, but rarely at a rate that can make it become epidemic.

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Bell G, MacLean C. The Search for ‘Evolution-Proof’ Antibiotics. Trends Microbiol. 2018;26(6):471-483.
Andersson DI, Hughes D, Kubicek-Sutherland JZ. Mechanisms and consequences of bacterial resistance to antimicrobial peptides. Drug Resist Updat. 2016;26:43-57.
Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, et al. Structural mechanism for rifampicininhibition of bacterial rna polymerase. Cell. 2001;104(6):901-912.
Luria SE, Delbrück M. Mutations of bacteria from virus sensitivity to virus resistance. Genetics. 1943;28(6):491-511.
Baquero F, Coque TM. Widening the spaces of selection: evolution along sublethal antimicrobial gradients. MBio.2014;5(6):e02270.
Schmieder R, Edwards R. Insights into antibiotic resistance through metagenomic approaches. Future Microbiol.2012;7(1):73-89.
Low-Décarie E, Fussmann GF, Dumbrell AJ, Bell G. Communities that thrive in extreme conditions captured from afreshwater lake. Biol Lett. 2016;12(9).pii: 20160562.

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