According to Aristotle, in order to be persuasive, a physician must embody Ethos (ethics or character), Logos (logic), and Pathos (passion or emotion). These universal principles are valid even today. The use and abuse of attribution and of fear in persuasion are discussed, as are ‘sleeper effect’ and persuasion of a procrastinator. Tips for persuading patients for organ donation and other advanced skills like ‘mental judo’ are then discussed. The thin line between ethical motivation and unethical manipulation is highlighted. The finer points have been adopted from management sciences and adapted for clinical interviews. The end of chapter exercises are designed to provide effective teaching-learning experiences of the various skills highlighted in the chapter.