Is a chronic blistering disease of middle-age characterized by acantholysis and bulla formation in epidermis basal layer? Types: Pemphigus vulgaris and vegetans, P. Foliaceus. Aetiology: Autoimmune, association of HLA 10 and DRW4 in Jews and Japanese, drug -like D-penicillamine, captopril and rifampicin produce pemphigus like picture. Clinical features: Mucous membrane lesions: fifty percent of patients with oral lesions, skin lesions follow 5 to 6 months after mucous lesions, characterized by small, flaccid, bullae mostly filled with clear fluid but rarely with pus. Site: Face, neck, trunk, pressure points axillae but may occur anywhere, Nikolsky’s sign is positive. Pemphigus vegetans is a variant of pemphigus vulgaris. Pemphigus Foliaceus and erythematosus: Probably a benign type of pemphigus with formation very superficial in epidermis. Investigations: Tzanck smear, skin biopsy, levels of circulating antibodies. Treatment: Corticosteroids, dose 1-2 mg/kg body weight. Initially a high dose to suppress bulla formation is given later to maintenance dose of 15 to 20 mg of prednisolone. Other immunosuppressant can be given. Specific: Immunosuppressants used as are follows-methotrexate 0.2 to 0.5 mg/kg body weight in 3 doses at 12 hourly, cyclophophamide-1 to 3 mg/kg/day, azathioprine-2.5 mg/kg/day.