Is a reaction pattern of skin and mucous membrane too many different stimuli characterized by presence of erythematous maculopapular, of vesicles and or bullae? Aetiology: Immunological mechanism with immune complexes as basic aetiological factors. Etiologic factors of erythema multiforme. Viral infection, bacterial infection, drugs, connective tissue disorders, pregnancy, contact enzyme. Clinical feature: Maculopapular. Vesiculobullous form: Severe Bullous form (Stevens Johnson Syndrome) mucous membrane involvement, eyes severe catarrhal or purulent nctivitis present. Skin lesions they are variable range between vesicle, bullae, bullies and pustules. Constitutional systems: Respiratory, renal, and GIT involvement is known. Treatment: For mild and intermediate forms, only symptomatic treatment in the form of local bland application PP baths. Severe form: Corticosteroids are required to control severe systemic manifestations, 0.5-1 mg/kg body weight for 3 to 4 weeks. General treatment: Good diet, daily bath with PP solution.