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Chapter-43 AIDS

BOOK TITLE: Essential of Dermatology, Venereology and Leprosy

Author
1. Chattopadhyay SP
ISBN
9788180610172
DOI
10.5005/jp/books/11611_43
Edition
1/e
Publishing Year
2003
Pages
2
Author Affiliations
1. Armed Forces Medical College Pune, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan; Calcutta Medical and Research Institute, Kolkata, West Bengal, India
Chapter keywords
Immunodeficiency syndrome in homosexuals IV drug addicts, Infected blood transfusion, No effective treatment, Present day treatment with two nucleoside analogue with one NNRTI.

Abstract

AIDS first recognized in 1981. AIDS indicates presence of an underlying cellular immune deficiency in a patient with no known underlying cause other than HIV infection. (a) Homosexuals, (b) IV drug addicts, (c) Blood transfusion recipients, and (iv) Heterosexual partners. Immunology: (a) Decrease number of helper T-lymphocytes, (b) Absolute lymphopenia, and (c) Impaired response on skin testing. Virus: (i) 1983: lymphadenopathy associated virus (LAV). (ii) 1984: Human T-cell-lymphotropic virus Type III, now the virus is termed as human immunodeficiency virus (HIV). Diagnosis: (a) ELISA test—screening test and (b) Western blot test— confirmatory for HIV antibodies. Principle of treatment (as available today): Today nucleoside analogue (Zidovudine 200 mg TID and Lamivudine 150 mg BID) with one NNRTI (Non-nucleoside reverse transcriptase inhibitors), e.g. Nevirapine 200 mg TID or Delavirdine 400 mg TID give maximum therapeutic effect.

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