Fungi are rudimentary plants without leaves, roots or stalks and do not produce chlorophyll. Human pathogenic fungi are fungi imperfecta which reproduce through production of spores. Fungi are of two main types-dermatophyte-having true hyphae with septae, yeast-pseudohyphae. Fungal infection: Red round, oval lesions with peripheral scales and central clearing, cracked, scaly or bald area on scalp, cracks and fissures in between, pustules in hairy area. Symptoms of taste infection: Witch patches plaque, moist mucous surface orin intertriginous areas, and eroded lesions in perineal or genital locations, vaginal discharge. Diagnosis by clinical appearance, KOH examination (10%), woods light examination, culture in Sabouraud’s agar medium grows skin biopsy-PAS stained materials. Factors predisposing fungal infection: Obesity, injury to skin, topical corticosteroids, diabetes, immune deficiency. Antifungal therapy-local therapy: Clotrimazole, miconazole, tolnaftate in 1-2 percent, white field ointment, toilet of the skin. Systemic therapy—griseofulvin, tab ketoconazole 200 mg OD, fluconazole 150 mg/week. For candida infection keeps area dry, local nystatin, clotrimazole and miconazole, systemic: ketoconazole 200 mg for 2–4 weeks.