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Chapter-19 Serum Uric Acid Estimation

BOOK TITLE: Practical Biochemistry for Medical Students

Author
1. Raghu B
ISBN
9788180611063
DOI
10.5005/jp/books/10641_19
Edition
1/e
Publishing Year
2003
Pages
2
Author Affiliations
1. Asian Institute of Medicine, Science and Technology, Malaysia
Chapter keywords

Abstract

This chapter discusses serum uric acid estimation, where uric acid is the major product of the catabolism of the purine nucleotides adenosine and guanosine. Purines from catabolism of dietary nucleic acid are converted to uric acid directly but the bulk of purines ultimately excreted as uric acid in the urine arises from the degradation of endogenous nucleic acids. Uric acid is filtered at the glomerulus in the kidney and most of it is reabsorbed in the proximal tubule. Some uric acid is secreted at the tubules. Hyperuricemia can occur due to overproduction of uric acid or due to reduced renal excretion of uric acid. Hyperuricemia is frequently associated with gout, leukemia and lymphomas, toxemia of pregnancy and renal failure. Hypouricemia can result from an inherited deficiency of xanthine oxidase, severe hepatocellular disease or defective renal tubular reabsorption. Many methods are available for estimating serum uric acid which includes various chemical and enzymatic methods.

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