This chapter discusses blood flow through viscera, muscles and skin, where circulation through liver, intestine and spleen is known as splanchnic circulation. The liver receives blood from two sources and these two sources of blood supply mix in the distal portion of the hepatic sinusoids. Both the hepatic artery and portal vein are richly innervated by sympathetic vasoconstrictor noradrenergic fibers. Intestines receive a rich blood supply from superior and inferior mesenteric arteries, which anastomose extensively. Mesenteric blood vessels are supplied by sympathetic vasoconstrictor nerves. Spleen acts as a reservoir of blood. The metabolites increase capillary permeability leading to an increase in interstitial fluid. The vasculature of skin shows extensive arteriovenous anastomotic channels. The afferent impulse that continues towards the central nervous system is responsible for the sensation of pain. Axon reflex is the only reflex in the body, the pathway of which does not involve the central nervous system.