EXPORT CITATION

Chapter-25 Membranoproliferative Glomerulonephritis

BOOK TITLE: Principles and Practice of Pediatric Nephrology

Author
1. Sahney Shobha
ISBN
9788180613043
DOI
10.5005/jp/books/11074_25
Edition
1/e
Publishing Year
2004
Pages
4
Author Affiliations
1. Loma Linda UMC and Children’s Hospital, Loma Linda, California, USA
Chapter keywords

Abstract

Idiopathic membranoproliferative glomerulonephritis is primarily a disease of children, adolescents and young adults. It is uncommon before the age of six years and majority present in the age group of 8-16 years. There is a small female preponderance. Renal failure occurs in 50% by 10 years and 90% in 20 years. The disorder is classified into Type I, II or III, based on histology. There is a generalized increase in mesangial cells and matrix resulting in accentuation of glomerular lobulation. The glomerular capillary walls are thickened and, in some areas, duplicated because of interposition of mesangium between the glomerular basement membrane and the endothelial cell. Majority presents with nephrotic syndrome and some present with ANS picture. Some may present with asymptomatic hematuria with or without proteinuria.

Related Books

© 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved