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Chapter-54 Genetic and Developmental Renal Disease

BOOK TITLE: Principles and Practice of Pediatric Nephrology

Author
1. Vijayakumar M
2. Nammalwar BR
ISBN
9788180613043
DOI
10.5005/jp/books/11074_54
Edition
1/e
Publishing Year
2004
Pages
11
Author Affiliations
1. Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India, Government Medical College, Manjeri, Kerala, India, Pediatric Kidney Foundation, Chennai, Dr Mehta’s Hospitals Pvt Ltd., Chennai, Government Medical College, Kozhikode, Kerala, India, Mehta Children’s Hospital, Chetpet, Chennai, Tamil Nadu, India, Government Medical College, Kozhikode, Kerela, India, Mehta Children’s Hospital, Chennai, Tamil Nadu, Mehta’s Children Hospital, Chennai, Tamil Nadu, India, Mehta Children’s Hospital, Chennai, Tamil Nadu, India, Dr. Mehta’s Hospital; Chennai Pediatric Kidney Foundation, Chennai, India, Chennai Pediatric Kidney Foundation, Dr Mehta’s Hospitals Pvt. Ltd, Chennai, National Botanical Research Institute, Lucknow-226 001, India, Medical College, Alappey, Kerala, Manipal Institute of Nephrology and Urology, Manipal Hospital, Bangalore, Karnataka, India, Kanchi Kamakoti, Childs Trust Hospital, Chennai
2. Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India, Kanchi Kamakoti CHILDS, Trust Hospital, Chennai, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India, Institute of Child Health, Hospital for Children; Mehta Children Hospital, Chennai, Tamil Nadu, Mehta Children’s Hospital, Chennai, Tamil Nadu, India, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Mehta's Multispeciality Hospital, Chennai, Tamil Nadu, India, Institute of Child Health, Hospital for Children and Dr Mehta’s Children’s Hospital, Chennai, Tamil Nadu
Chapter keywords

Abstract

A genetic basis has been identified for a number of renal diseases. These include monogenic diseases like polycystic kidney disease, polygenic disorders like hypertension and ill-defined conditions like renal cell carcinoma and mitochondrial disease. Congenital malformations of the urinary tract cause neonatal death and a common cause of end-stage disease in children. The development of upper urinary tract from the ureterovesical junction to the kidney depends on an interaction between the ureteral bud and the metanephric blastema. This interaction leads to the transformation of mesenchymal cells into epithelial aggregates that ultimately form the glomeruli and proximal nephrons; the ureteral bud gives rise to the ureter, renal pelvis and collecting tubules. Damage to the developing kidney results from obstruction and increased ureteral back pressure due to urine formation by the metanephric kidney at 8 to 10 weeks of gestation.

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