Drug Screening Methods

by SK Gupta

Drug discovery and development is a challenging field of research requiring the synchronized efforts of medicinal chemists, natural chemists, pharmacologists, toxicologists and clinicians, and so on. The ultimate target of this team is to generate a safe and biologically active drug that is capable of stalling, if not reversing, the pathological events leading to disease condition. In the drug discovery program, the battery of tests and assay systems that evaluate the efficacy and safety of novel molecule in biological system occupy the center stage. Keeping in tune with the practically used techniques used in both academia and pharmaceutical industry, the book Drug Screening Methods outlines numerous methods utilizing molecular and fluorescence techniques. A complete section is devoted to the concept and basic techniques involved in novel drug discovery program. Special attention is given to novel methods based on genetically modified animals that stimulate the human condition as these help in not only understanding the pathogenesis, but also develop targets for therapeutic modalities. An overview is provided for major fields of investigation, such as drug absorption and metabolism, cancer biology, angiogenesis, apoptosis, AIDS, and autoimmune disorders. This book addresses the need for simple screening procedures that explicitly demonstrate the nuances of sympathetic, parasympathetic nervous system and gut motility to the students. Special care has been taken to develop chapters in the fields of ocular and cardiovascular pharmacology. Considering the renewed interest in outsourcing novel drugs from natural source, a separate chapter dealing with assay procedures for screening the pharmacological activity of herbal drugs is written. Every drug has a therapeutic effect, which is desired, along with an unwanted side effect. The methods for assessing safety of novel molecules are discussed. Toxicity studies are critical as it is on their basis that the toxicity and efficacy profile of a novel molecule can be weighed and its future determined.

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Book Detail

Editor
1. Gupta SK
Editor's Affiliation
1. Institute of Clinical Research (India), New Delhi, India
ISBN
9788180613975
Speciality
Pharmacology
DOI
10.5005/jp/books/10243
Edition
1/e
Publishing Year
2004
Pages
507
Book Type
Professional

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