This chapter discusses diseases of salivary glands, which may be non-neoplastic lesions and salivary gland tumours. Acute suppurative sialadenitis may involve parotid or submandibular gland. Chronic sialadenitis is infection of salivary glands can lead to firm, mild enlargement of the gland with repeated acute infections. Massage of gland produces scanty secretions at the opening of the duct. Mumps is also called viral parotitis and is usually seen in children up to twelve to fifteen years of age. Complications of mumps are viraemia causing orchitis, pancreatitis, meningitis, and encephalitis. Frey’s syndrome is the condition consists of sweating and flushing of skin of face during mastication. Sialolithiasis are formed when calcium phosphates are deposited around the debris and mucus. Sialadenosis is a non-specific, noninflammatory, non-neoplastic enlargement of salivary gland usually the parotid. Pleomorphic adenoma is also called mixed parotid tumour. Other benign tumours may be oncocytoma, monomorphic adenomas, haemangiomas, lymphangiomas and lipomas.