Abnormal uterine bleeding is a common gynecological problem accounting for nearly 15% of the outpatient attendance and almost 20% of the gynecological operations. Abnormalities of cycle length, duration of flow and amount of blood loss are causes for concern for the patient and her relatives. It may be due to organic causes or as a result of the dysfunction of the hypothalamus-pituitary-ovary-endometrial axis—designated as dysfunctional uterine bleeding (DUB). Abnormal uterine bleeding is clinically grouped as bleeding abnormalities in childhood and adolescence, in the reproductive age group and in perimenopause—as the etiology and approach to management is entirely different in these groups of patients. Majority of cases of dysfunctional uterine bleeding may be treated medically, surgical options being considered for those resistant to medical intervention. This chapter deals mainly with the diagnosis and management of DUB although other causes of abnormal uterine bleeding are mentioned, to stress the point that DUB is a diagnosis of exclusion and that all the organic causes of abnormal uterine bleeding are to be considered in the clinical approach to DUB. Dysfunctional uterine bleeding (DUB) is a symptom complex that includes any condition of abnormal uterine bleeding in the absence of pregnancy, neoplasm, infection and other pathology of the female genital tract as well as other systemic causes of abnormal bleeding. Such bleeding is most often the result of endocrinologic dysfunction.