Salivary gland disease is the clinical area in which all the doctors, the ENT, the Oral surgeons, Oral Medicine and Radiology, General medicine and family practitioners all need to work together so that patient gets the maximum benefit from their expertise. All dentists must have a sound knowledge of the pathogenesis of the salivary gland diseases and what labels are applied to each diagnostically. In testing, the non-invasive diagnostic procedures must be preferred over invasive ones, and in general the treatment should be chosen such as not to portray a knife happy surgeon. How the saliva or lack of it can affect the dynamics of the oral ecosystem should be clearly understood. The human beings are blessed with three pairs of major salivary glands and many millions of minor salivary glands. They secrete saliva, which helps in lubrication, in taste perception and in overall protection of teeth and Oral mucosa through the Immunoglobulins and other antibacterial factors. These glands are prone to a special set of diseases, which will be touched upon in this section. Navazesh mentions four clinical measures to diagnose the hypofunction in the salivary gland. Dryness of the lips, dryness of the buccal mucosa and absence of saliva produce by gland palpation and the DMFT scores. He mentions the normal salivary flow rates to be 0.12 to 0.16 ml/min.