With the advent of miracles of modern medicine, the strong pharmacological agents, the pacemakers, the dialysis units and the digital imaging, more and more dental patients with serious medical compromise are likely to walk into dental clinic. It is a practicing dentist’s duty to recognize such medical deviations and then take treatment decisions. This chapter tries to address a very vast area of knowledge of medically compromised dental patient. This chapter is merely indicative of different risks and when the dental surgeon is in doubt always follow a golden rule – take the phone and talk to the specialist. In all cases patients taking any medical treatment need written consent from the physician or family doctor about the fitness to receive dental treatment. All these consent notes need to be stapled to the primary dental record of the patient and entered in his computer file. If the dentist feels that after his treatment the patient might need physician’s care then clear written instructions and telephonic follow-up is a good way to develop healthy rapport for total health care of the patient.