The principle of LKP for Mooren’s ulcer is to thoroughly remove necrotic ulcerative cornea and to reconstruct the corneal anatomy. In 1975, Christiansen and Arentsen reported success in one case of Mooren’s ulceration using an annular “doughnut” lamellar graft. Because the central cornea subsequently melted, a total corneal lamellar graft was performed and the patient remained ulcer free. A report by McDonnell on recurrent Mooren’s ulceration in recipient tissue but not graft tissue also supported the concept of a host-specific immunologic reaction. In 1994, Bessant DAR and Dart JK treated 10 cases of peripheral ulcerative keratopathy (eight with perforations) successfully with LKP. The main approaches to the management of Mooren’s ulcer include conjunctival excision, kerato-epithelioplasty during which fresh donor corneal lenticules are placed near the distal side of the ulcerated area and securely sutured on to the bare sclera, LKP, and immunosuppressive treatment. During LKP, which is widely used to treat Mooren’s ulcer, antigenic corneal targets are removed, immunologic reactions are prevented, anatomic structure is reconstructed, corneal perforation is prevented, and the vision improves. The combined use of amniotic membrane and lamellar keratoplasty (LKP) in peripheral ulcerative diseases such as Mooren’s corneal ulcer is often an effective surgical modality in managing these challenging cases. Such a surgical approach needs to be supplemented with the required immunosuppression for a successful outcome. This chapter presents the various aspects of the amniotic membrane, the clinical manifestations and the surgical techniques in the management of Mooren’s corneal ulcer.