Lamellar keratoplasty (LKP) is an operation in which diseased corneal tissue is removed and replaced by lamellar corneal tissue from a donor. The procedure is performed either to improve vision (optical keratoplasty) or to provide structural support for the cornea (tectonic keratoplasty). Anterior LKP (ALKP) can be performed to replace a portion of the corneal thickness when the endothelium is healthy. Depending on the location of the corneal abnormality, it may be sufficient to replace just the anterior layers by performing an ALKP or the full-thickness corneal stroma without the endothelium by performing a deep lamellar keratoplasty (DLK) which is also an ALKP procedure. Postoperative care that includes appropriate immunosuppressive therapy often affects the results of optical keratoplasty and tectonic keratoplasty. In this chapter, we also discuss the postoperative management of a keratolimbal allograft, a form of LKP with stem cell transplantation.