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Chapter-25 Infusion of Hematopoietic Stem Cells

BOOK TITLE: Handbook of Blood Banking & Transfusion Medicine

Author
1. Sauer-Heilborn Annette
ISBN
9788180617188
DOI
10.5005/jp/books/10339_25
Edition
1/e
Publishing Year
2006
Pages
10
Author Affiliations
1. An der Quelle 10, 30539 Hanover, Germany
Chapter keywords
Hematopoietic stem cell (HPC) infusion, cryopreservation, umbilical cord cells.

Abstract

Although an HPC infusion can be seen as a special blood transfusion, it differs in several points. Thawed blood transfusions contain DMSO, they are cold when infused, they have a high osmolality and they contain cell debris and some free hemoglobin. ABO-compatible products are sometimes needed and infused because of the importance of HLA matching. Adding the cryoprotectant, alterations resulting from freezing and thawing and transfusions across the ABO barrier require special precautions, during and after the transfusion.

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