Management of Gestational Trophoblastic Tumors (GTT)

by Sumita Mehta, Vijay Zutshi, Swaraj Batra

The persistent trophoblastic tumors or disease (PTD) like invasive mole to choriocarcinoma responds dramatically to chemotherapy. There is no other malignancy in which remission rate can be expected above 90 percent. This important monograph, through its well defined four sections, provides basic and relevant information on trophoblast in health and disease, reviews the advances made in the field of diagnosis and discusses principles of management based on clinical experience accumulated in the Dept. of Obstetrics and Gynecology. Briefly covers the normal conception and implantation, trophoblast in health and disease, current FIGO criteria for diagnosis of PTD, detailed pretreatment evaluation and scoring, various management protocols for low-and high-risk PTD, prevention and treatment of toxicities due to chemotherapy. It also depicts few ultrasound pictures of the cases and histological slides of invasive mole and choriocarcinoma. One should also suspect PTD in a patient of reproductive age group, who presents with hemoptysis with chest findings, headache, neurological signs or bleeding per rectum, where no other diagnosis fits into the clinical picture. This monogram is going to be useful for all doctors practicing Obstetrics and Gynecology.

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