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Chapter-05 The Blood and the Mononuclear Phagocyte System

BOOK TITLE: Textbook of Human Histology

Author
1. Singh Inderbir
ISBN
9788180618093
DOI
10.5005/jp/books/10913_5
Edition
5/e
Publishing Year
2006
Pages
19
Author Affiliations
1. 52, Sector One, Rohtak 124002, 52, Sector One, Rohtak 124003, 52, Sector One, Rohtak 124004, 52, Sector One, Rohtak 124005, 52, Sector One, Rohtak 124006, 52, Sector One, Rohtak 124007, 52, Sector One, Rohtak 124008, 52, Sector One, Rohtak 124009, 52, Sector One, Rohtak 124010, 52, Sector One, Rohtak 124011, 52, Sector One, Rohtak 124012, 52, Sector One, Rohtak 124013, 52, Sector One, Rohtak 124014, 52, Sector One, Rohtak 124015, 52, Sector One, Rohtak 124016, 52, Sector One, Rohtak 124017, 52, Sector One, Rohtak 124018, 52, Sector One, Rohtak 124019, 52, Sector One, Rohtak 124020, 52, Sector One, Rohtak 124021, 52, Sector One, Rohtak, 52, Sector 1, Rohtak, Haryana, India, 52, Sector One Rohtak, 52, Sector One, Rohthak, India
Chapter keywords
lymphocytes, macrophage, blood, phagocytic cells, differentiation factors, erythrocytes, tissues, peritoneum, antigen presenting cells, spleen, littoral cells, mononuclear phagocyte, bone marrow, stem cells, granulocytes, multi-lobed nucleus, myeloblast, intermediate erythroblasts, polyphyletic theory, postnatal life, platelets

Abstract

This chapter discusses various aspects of the blood and the mononuclear phagocyte system. Blood is regarded as a modified connective tissue because the cellular elements in it are separated by a considerable amount of intercellular substance. Differences between erythrocytes and leucocytes, facts about neutrophils, basophils, and eosinophils, and formation and circulation of lymphocytes, are some topics discussed in detail. T-lymphocytes specialize in recognizing cells that are foreign to the host body such as fungi, virus infected cells, tumor cells, or cells of another individual. The destruction of foreign cells by T-lymphocytes is responsible for the ‘rejection’ of tissues or organs grafted from one person to another. Such rejection is one of the major problems in organ transplantation. Cells of mononuclear phagocyte system include monocytes of blood, macrophage cells, microglial cells, macrophages in pleura, free macrophages, and dendritic cells. Antigens phagocytosed by macrophages are partially digested by lysosomes. Some remnants of these pass to the cell surface where they form complexes with the MHC antigens.

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