Increased longevity is one of the modern world’s great successes, but long life without health is an empty prize. Therefore, it is the responsibility of the health care providers to look for the ways to maintain and improve their functional abilities, though aging as a rule remains a fact of life. Conventional wisdom tells us that creaky joints, lack of appetite and a closet full of medicines are an inevitable part of aging. But an increasing number of health professionals across the globe are endorsing the view that an appropriate exercise program can help the elderly sail through their golden years. Consequently, this chapter deals with response to exercise involving the coordinated interplay between the physiological systems in elderly.