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Chapter-15 Calcium Channel Blockers

BOOK TITLE: Textbook of Pharmacology for Dental and Allied Health Sciences

Author

1. Udaykumar Padmaja

ISBN

9788184481495

DOI

10.5005/jp/books/10941_15

Edition

2/e

Publishing Year

2007

Pages

Author Affiliations

1. Father Muller Medical College, Mangaluru, Karnataka, India

Chapter keywords

Abstract

Abstract

Calcium channel antagonists inhibit the entry of calcium by blocking the L-type of calcium channels. This decreases calcium current and calcium entry into cardiac and vascular smooth muscle cells resulting in vasodilation and decreased myocardial contraction. Nifedipine is a potent vasodilator while verapamil has prominent myocardial depressant effects. CCBs are used in angina pectoris, hypertension, arrhythmias, peripheral vascular diseases and verapamil is also used in migraine.

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