Epilepsy is a common neurological abnormality characterized by recurrent seizures often accompanied by episodes of unconsciousness and/or amnesia. Seizures may be partial or generalized seizures. Generalized seizures may be absence seizures, atonic seizures and tonic-clonic seizures. Status epilepticus is continuous or recurrent seizures of any variety without recovery of consciousness between the attacks. Antiepileptic’s can act by blockade of sodium channels, low threshold current or by enhancing gamma mediated inhibition. Phenytoin has good anti-seizure activity and is one of the most active drugs against generalized tonic–clonic and partial seizures. Phenobarbitone has specific antiepileptic activity and is still in use in developing countries because of its efficacy and low cost. The antiepileptic actions of carbamazepine are similar to phenytoin and are one of the most commonly used antiepileptic’s. It is also useful in trigeminal and glossopharyngeal neuralgia and in bipolar mood disorder. Ethosuximide is the drug of choice for absence seizures. Valproic acid acts by multiple mechanisms and is a very effective antiepileptic drug useful in many types of epilepsies including absence seizures, partial and generalized tonic-clonic seizures. Diazepam is the drug of choice in status epilepticus. Newer antiepileptic’s, gabapentin, lamotrigine, vigabatrin, topiramate, felbamate and zonisamide are presently used as add on drugs in epilepsy. Epilepsy and dentistry—when patients on antiepileptics are admitted for dental procedures, certain precautions are to be taken.