The purpose of this chapter is to first of all describe the PML (Presbyopic Multifocal LASIK, the patented technique that we studied and developed at the Istituto Laser Microchirurgia Oculare, Brescia, Italy), and then to show the customization of this treatment through clinical cases. In this chapter the reader will find some clinical cases to better understand the customized approach for the treatment of presbyopia with PML (one myopic-presbyope, one hyperopic-presbyope, one emmetropic-presbyope and one mixed astigmatic-presbyope). PML can be performed on presbyopic myopes, hyperopia, astigmatism, mixed astigmat and emmetropes. Multifocality on the cornea is created using a multi-step treatment in which several independently calculated ablations are performed at various optical zones. It is a procedure that is highly customizable for each patient’s optical needs.