Age-related physiological changes do occur in gastrointestinal and hepatobiliary system but magnitude and intensity of derangement is appreciably less as compared to other systems of the body. However, under conditions of stress these can manifest in a significant manner. Swallowing, gastric emptying, digestion and absorption of nutrients are invariably affected in aged patients under such circumstances. Propensity towards neurogenic bowel disturbances, gastrointestinal bleeding and malabsorption should be considered as comorbities while treating aged patients. Chronic hepatitis (A, B, and C) and autoimmune hepatitis are the other disorders which a clinician should keep in mind while dealing with this category of patients. Polypharmacy in older patients, presenting with drug induced metabolic disorders, is another area that should be taken care of.