A 27-year-old woman is diagnosed with asymptomatic HIV in pregnancy. Her initial laboratory studies show a CD4 count of 550 cells/mm3 and a HIV RNA level of 20,335 copies/ml. An ultrasound shows a normal intrauterine pregnancy of 10 weeks gestation. Guidelines for selecting two drugs NRTI will be same as discussed in earlier chapter. Zidovudine OR Stavudine PLUS Lamivudine. As far as the choice of third drug is concerned as per adult guidelines for non pregnant patients it should be from the class of drug NNRTI or PI. As discussed Efavirenz is contraindicated for use in pregnant women and Nevirapine should not be prescribed if CD4 is more than 250 cells/mm3. So, PI becomes the obvious choice as third drug in this case to complete the optimal three drug regimen.