Chemical neurolysis or destruction of nerves either by the application of chemical neurolytic agents, which is an age-old accepted technique of achieving a pain relief in the chronic intractable pain patients, still continues to be one of the main armamentarium. Newer techniques like Radiofrequency lesioning and Cryoprobe have taken a front seat in the patient care recently and these are getting further improvised to produce effective prolonged analgesia for chronic pain syndromes. But, these techniques require specialized training, in depth knowledge of neural anatomy and understanding of chronic pain physiology. So, there application should be reserved only in painful conditions where conventional conservative pain management fails.