The skin covers the surface of the body and consists of two main layers; the surface epithelium or epidermis and the subjacent connective tissue layer, the corium or dermis. The epidermis has stratified squamous epithelium. In sections four layers can be distinguished. The stratum malpighian which may be sub-divided into the stratum germinativum (stratum basale); the layers of cells in contact with dermis and a layer of variable thickness above which is called as stratum spinosum (prickle cell layer). The next layer is the stratum granulosum or granular layer, and then follows the stratum lucidum or clear layer and the stratum corneum or horny layer. The keratinized portion is formed by stratum corneum and lucidum. Dermis consists of two layers outer layer is in contact with the epidermis and is usually uneven and is thrown into papilla known as papillary layer and deeper portion of dermis is called reticular layer. Functional aspect with clinical conditions associated is also given. Relevant photomicrographs are given in atlas provided at the beginning of book.