Plaque Control is the removal of microbial plaque and the prevention of its accumulation on the teeth and adjacent gingival tissues. Besides it also deals with the prevention of Calculus formation. Plaque control is the most essential step towards maintaining a proper and a healthy Oral Environment. This chapter explains plaque, stages of plaque formation, disclosing solution, various agents to remove plaque from the oral cavity, techniques of tooth brushing, and classification of chemotherapeutic antiplaque agents. It also tells guidelines for home oral hygiene.