In the region of wrist there are eight carpal bones arranged in proximal and distal rows. The carpal bones present concavity anteriorly which is converted into carpal tunnel due to the flexor retinaculum. On the dorsum of the wrist there is an extensor retinaculum, having six compartments underneath meant for the passage of various tendons. Carpal tunnel give passage to nine tendons, i.e. four of flexor digitorum sublimis, four of flexor digitorum profundus one of flexor pollicis longus and the median nerve. Sublimis and profundus are provided with a synovial bursa known as ulnar bursa while the tendon of flexor pollicis longus is accompanied by the radial bursa. Muscles of the flexor compartment are arranged in two groups superficial and the deep. Pronator teres, flexor carpi radialis, flexor digitorum sublimis, palmaris longus and the flexor carpi ulnaris are the members of the superficial group. Deep group of muscles of the forearm are flexor pollicis longus, flexor digitorum profundus and the pronator quadratus. The median nerve passes between the two heads of pronator teres muscle and the ulnar nerve passes between the two heads of flexor carpi ulnaris. Median nerve supplies all the muscles of the flexor compartment of the forearm except the flexor carpi ulnaris and the medial half of flexor digitorum profundus. Results of injury of the median nerve include pointing index and Semian hand. Causes of carpal tunnel syndrome are tubercular tenosynovitis of the flexors of fingers, rheumatoid arthritis, and hypothyroidism, hypertrophy of flexor retinuculum and late complication of colles fracture.