Biostatistics, the science of management of uncertainties in health and disease, deals with the quantitative rather than the qualitative aspect of health and disease. The cornerstone of all biostatistical endeavors is the measurement through which all quantities are obtained and, thereafter, uncertainties and variations studied. This involves systemic collection, organization, analysis and interpretation of numerical data pertaining to health and disease. Medical statistics deals with statistics pertaining to medical sciences, data related to human diseases in particular. The term, morbidity statistics, denotes statistics pertaining to sickness. The statistics dealing with births, deaths and marriages fall under the category, vital statistics. The highlights of the biostatistics part of the Chapter include data, information and intelligence, types of studies, statistical averages, measures of variation (dispersion), percentile, significant value, etc. The highlights of the medical informatics part include medical informatics, telemedicine, cyber medicine and internet. In future we expect a “quantity leap”, meaning that in addition to the very high internet speed, sight, sound and even touch will be integrated through powerful computers, displays and networks. This is likely to be followed by the so-called “quality leap” where the web is likely to have machine understandable information with the help of intelligent software agents. In nutshell, the machine itself will act intelligently in delivering future health care services.