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Chapter-02 Radionuclide Production

BOOK TITLE: Principles and Practice of Nuclear Medicine and Correlation Medical Imaging

Author
1. Lele RD
ISBN
9788184484816
DOI
10.5005/jp/books/10672_2
Edition
1/e
Publishing Year
2009
Pages
8
Author Affiliations
1. Jaslok Hospital and Research Center, Mumbai, India, Grant Medical College, and JJ Hospital, Mumbai, e-mail: lele1@vsnl.com, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India
Chapter keywords

Abstract

Radionuclide production involves three sources—cyclotron, nuclear reactor and radionuclide generator. Also, details of these sources have been provided. This chapter provides details and characteristics of cyclotron and reactor produced radionuclides. The availability of cyclotron-produced radionuclides of the fundamental elements of living matter-carbon, nitrogen oxygen and the availability of PET (Positron emission tomography) has enabled exploration of a number of physiologic metabolic and pharmacologic processes in the living human body including the brain. In view of the short-half life, the cyclotron has to be hospital–based. Rubidium and Ga-68 generators are portable but very expensive. Long-lived radionuclides from cyclotrons- Iodine-123, Thallium-201, Gallium-67 have wider applications with SPECT imaging (single photon emission computed tomography), compared to PET.

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