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Chapter-51 Evolution of Chemotherapeutic Regimens in the Treatment of Tuberculosis and their Scientific Rationale

BOOK TITLE: Tuberculosis

Author
1. Balasubramanian Rani
2. Ramachandran Rajeswari
ISBN
9788184485141
DOI
10.5005/jp/books/10992_51
Edition
2/e
Publishing Year
2009
Pages
17
Author Affiliations
1. Tuberculosis Research Center, [Indian Council of Medical Research], Mayor Ramanathan Road, Chetpet, Chennai, India, Tuberculosis Research Center (ICMR), Mayor VR Ramanathan Road Chetput, Chennai, Tamil Nadu, India, Tuberculosis Research Centre (ICMR), Mayor VR Ramanathan Road, Chetput, Chennai
2. Tuberculosis Research Centre [Indian Council of Medical Research], Mayor V.R. Ramanathan Road, Chetpet, Chennai, India, Tuberculosis Research Center (ICMR), Mayor VR Ramanathan Road Chetput, Chennai, Tamil Nadu, India, Tuberculosis Research Centre (ICMR), Mayor V R Ramanathan Road, Chetput, Chennai
Chapter keywords

Abstract

This chapter begins with an overview of the scientific basis of antituberculosis treatment including the need to use multiple drugs for prolonged periods. Current recommendations for standard regimens are presented. The rationale behind intermittent treatment is covered in great detail. Evolution of short-course chemotherapy regimens is traced. The terminology of standard antituberculosis regimens is clarified. Efficacy of various treatment regimens in smear positive TB, smear-negative TB and extrapulmonary TB are presented. The definition of adverse events due to antituberculosis treatment and monitoring for these are explained. Treatment of TB in HIV/AIDs patients is also covered.

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