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Chapter-12 Pharmacogenetics

BOOK TITLE: Essentials of Human Genetics

Author

1. Purandarey Hema

ISBN

9788184485356

DOI

10.5005/jp/books/10279_12

Edition

2/e

Publishing Year

2009

Pages

Author Affiliations

1. Nicholas Piramal Group of Laboratories, Mumbai, India, Birth Defects Center, Mumbai, Maharashtra, India, Centre for Genetic Health Care, SRL Diagnostic Services Private Limited (Genetics), Mumbai, Maharashtra, India, Medgenome Centre for Genetic Healthcare, Mumbai, Maharashtra, India

Chapter keywords

Abstract

Abstract

Pharmacogenetics is the study of genetic variation resulting in changes to metabolic pathways which gives rise to a differing response to an adverse effect or a therapeutic defect of a drug. The differing response may be due to polymorphism at single nucleotide polymorphism. Based on this mutation analysis the toxicity of the drugs can be assessed and effective medicines selected.

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