This chapter discusses small bowel, colon, appendix, in gynecological surgery. Diverticulitis, appendicitis, meckel\'s diverticulum, volvulus, and gynecologic conditions that affect the gastrointestinal tract, are some topics discussed in detail. Enterotomy may be an incidental occurrence during dissection or an intentional orchestrated maneuver during gastrointestinal surgery. Cautery or sharp dissection can result in enterotomy, which commonly occurs during adhesiolysis. The skill and comfort level of the laparoscopic surgeon determines whether the defect can be successfully repaired laparoscopically or whether laparotomy is required. Surgery in previously irradiated patients requires incision to be made in a location beyond the radiation field. If resection is unavoidable, the suture line can be reinforced by wrapping the anastomosis with omentum, which elicits support of exogenous blood supply.