The cutaneous glands that serve vital functions include sebaceous, eccrine and apocrine sweat glands. This chapter provides a detailed description of acne vulgaris related to its pathogenesis, clinical features, inflammatory variants and special types with a comprehensive discussion on the various treatment modalities. A separate note on perioral dermatitis and rosacea is given. The disorders of eccrine and apocrine are discussed in succinct with emphasis on the key clinical features and treatment.