EXPORT CITATION

Chapter-10 Terminal Vascular Network of the Cervix and Angiogenesis of Cervical Neoplasia

BOOK TITLE: Cytology and Colposcopy in Gynecological Practice

Author
1. Stafl Adolf
ISBN
9788184485844
DOI
10.5005/jp/books/10194_10
Edition
1/e
Publishing Year
2009
Pages
10
Author Affiliations
1. Advanced Institute of Fertility, Milwaukee, Wisconsin, USA
Chapter keywords

Abstract

Changes in the terminal vascular network of the cervix represent one of the most important diagnostic factors in colposcopy. The terminal vessels can be observed in the colposcope in magnification 16x to 40x. To increase the contrast of the vessels, green filter can be used. Many years ago Staff developed a special histochemical method for alkaline phosphatase. This technique will allow us to study the vessels even from small biopsies from the cervix. Vascular pattern in CIN can be increased intercapillary distance, punctations or mosaic. In Invasive lesions there is neovascularisation leading to formation of immature blood vessels on the surface. This is caused by the release of angiogenic molecules by the tumour. It was in 1971 that Folkman introduced the concept of angiogenesis of tumours. Folkman and Cao in 1983 isolated the tumour angiogenesis factors and later in 1998 they also isolated the angiogenesis blocking factors, angiostatin and endostatin. This opened a new chapter in cancer therapy.

Related Books

© 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved