The goal of Colposcopy is to distinguish between normal and suspicious findings. Precise correlation between colposcopic and histologic findings requires guided biopsies. Colposcopic–histologic correlations require good colpophotographs and meticulous histology of conization specimens with serial sections. Carcinoma in situ (CIN 3, HG SIL) lies above (i.e. further toward or in cervical canal) than CIN 1 (LG-SIL). Benign Acanthotic epithelium is located most distally. All kinds of epithelia are found within the last gland, but they follow these rules. Convincing histologic evidence that CIN (SIL) can arise outside the transformation zone, in the original squamous epithelium. There are two completely different types of mosaics and punctuations: those within and those outside the transformation zone. They differ in their morphogenesis and in their “malignancy index”.