EXPORT CITATION

Chapter-13 Anticataract Agents

BOOK TITLE: Drug Screening Methods: Preclinical Evaluation of New Drugs

Author
1. Srivastava Sushma
2. Joshi Sujata
ISBN
9788184486186
DOI
10.5005/jp/books/10244_13
Edition
2/e
Publishing Year
2009
Pages
18
Author Affiliations
1. Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), MB Road, Pushp Vihar, Sector-3, New Delhi (India), All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India, Delhi Institute of Pharmaceutical, Sciences and Research, Pushp Vihar, Sector -3, New Delhi, India, Delhi Institute of Pharmaceutical, Sciences and Research, Pushp Vihar Sector-3, New Delhi, India, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), University of Delhi, New Delhi, India, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, Pushp Vihar, Sector-3, New Delhi, India, Indian Pharmacopoeia Commission, Ministry of Health and Family Welfare, Government of India, Ghaziabad, Uttar Pradesh, India
2. All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029 (India), All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Chapter keywords

Abstract

Cataract, a multifactorial disease, occurs mainly due to the formation of large protein aggregates in the lens. Post translational modifications of lens crystallins such as oxidation, glycation, Schiff’s base formation, carbamylation, transamidation, phosphorylation and proteolysis lead to clouding of the lens. Several factors like genes, socioeconomic status, illiteracy, malnutrition, diarrhea, diabetes, myopia, renal failure, hypertension, sunlight exposure, smoking, steroids etc. are responsible for the development of cataract. During the last two decades, extensive research inputs have been made to delineate the etiology of cataract. Efforts have been directed to delay the onset and slow down the progression of cataract by a variety of agents. These agents have been classified into different categories; their anti-cataract properties have been evaluated in different experimental models of cataract. A few commonly used in vitro and in vivo experimental models are described.

© 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved