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Chapter-23 Drugs Acting on Parasympathetic Nervous System

BOOK TITLE: Drug Screening Methods: Preclinical Evaluation of New Drugs

Author
1. Gupta Rachna
2. Agarwal Renu
3. Bhardwaj RK
ISBN
9788184486186
DOI
10.5005/jp/books/10244_23
Edition
2/e
Publishing Year
2009
Pages
8
Author Affiliations
1. Indraprastha Apollo Hospitals, New Delhi, India, Lady Hardinge Medical College, New Delhi (India), All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India, University College of Medical Sciences, GTB Hospital, Shahdara, Delhi, India
3. Rutgers University, New Jersey, (USA), Rutgers University, New Jersey, USA
Chapter keywords

Abstract

The drugs with potential cholinergic or anticholinergic activity can be screened using various animal models such as intestinal spasmolytic activity in mice, continuous cystometry in rats, guinea pig bronchospasm. Isolated tissue preparations include guinea pig ileum, isolated eye of rodents, isolated frog rectus, isolated rat aorta, guinea pig trachea, guinea pig isolated heart that can be used to study drugs acting on parasympathetic system.

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