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Chapter-26 Antipsychotic Agents

BOOK TITLE: Drug Screening Methods: Preclinical Evaluation of New Drugs

Author
1. Mathur Rajani
ISBN
9788184486186
DOI
10.5005/jp/books/10244_26
Edition
2/e
Publishing Year
2009
Pages
10
Author Affiliations
1. Delhi Institute of Pharmaceutical Sciences and Research (Delhi University), Pushp Vihar, New Delhi, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), MB Road, Pushp Vihar, Sector-3, New Delhi (India), All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India, Delhi Institute of Pharmaceutical, Sciences and Research, Pushp Vihar, Sector-3, New Delhi, India, Delhi Institute of Pharmaceutical, Sciences and Research, Pushp Vihar Sector-3, New Delhi, India, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), University of Delhi, New Delhi, India, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, Pushp Vihar, Sector-3, New Delhi, India, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, India
Chapter keywords

Abstract

Most of the currently available models for antipsychotic agents are valid only to make predictions with respect to pharmacotherapy and show pharmacologic isomorphism. These models provide least insight into the processes underlying the disease. Animal models with face validity are based on symptom similarity and exhibit behavioral isomorphism like catatonia, stereotypy, impaired performance and social withdrawal. Catalepsy in rodents, amphetamine/apomorphine induced stereotypy, phencyclidine induced bizarre pattern of locomotor activity, conditioned avoidance reflex etc. fall into this category.

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