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Chapter-27 Antidepressant Agents

BOOK TITLE: Drug Screening Methods: Preclinical Evaluation of New Drugs

Author
1. Mathur Rajani
ISBN
9788184486186
DOI
10.5005/jp/books/10244_27
Edition
2/e
Publishing Year
2009
Pages
8
Author Affiliations
1. Delhi Institute of Pharmaceutical Sciences and Research (Delhi University), Pushp Vihar, New Delhi, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), MB Road, Pushp Vihar, Sector-3, New Delhi (India), All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India, Delhi Institute of Pharmaceutical, Sciences and Research, Pushp Vihar, Sector-3, New Delhi, India, Delhi Institute of Pharmaceutical, Sciences and Research, Pushp Vihar Sector-3, New Delhi, India, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), University of Delhi, New Delhi, India, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, Pushp Vihar, Sector-3, New Delhi, India, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, India
Chapter keywords

Abstract

A major problem in the search for new antidepressant drugs is the lack of animal models that resemble depressive illness in humans and are selectively sensitive to simulate effective antidepressant treatments. Most of the classical screening methods are inadequate for detecting novel antidepressant drugs. Water wheel model, learned helplessness, isolation-induced hyperactivity, tail suspension etc are some of the methods.

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