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Chapter-28 Antiepileptics

BOOK TITLE: Drug Screening Methods: Preclinical Evaluation of New Drugs

Author
1. Mittal Rajan
ISBN
9788184486186
DOI
10.5005/jp/books/10244_28
Edition
2/e
Publishing Year
2009
Pages
23
Author Affiliations
1. Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh (India), All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India, Dr Reddy’s Laboratory Ltd, Hyderabad (Andhra Pradesh), India
Chapter keywords

Abstract

Epilepsy, in contradistinction to seizures, is a chronic disorder characterized by recurrent seizures. Pathophysiology of epilepsy involves alterations in voltage-dependent ion channels: reduction in inhibitory, i.e. GABA-mediated or increase in excitatory, i.e. glutamate-mediated inputs. Discovery of newer genetic models of epilepsy and use of models of injury-induced epilepsy based on electrically or chemically induced status epilepticus are recommended by NIH. In order to study the antiepileptic effect of drugs and discovering their mechanism of action, various in vitro and in vivo models of epilepsy have been devised which are discussed in the chapter.

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