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Chapter-35 Antiulcer Agents

BOOK TITLE: Drug Screening Methods: Preclinical Evaluation of New Drugs

Author
1. Mittal Rajan
2. Bhardwaj RK
ISBN
9788184486186
DOI
10.5005/jp/books/10244_35
Edition
2/e
Publishing Year
2009
Pages
9
Author Affiliations
1. Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh (India), All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India, Dr Reddy’s Laboratory Ltd, Hyderabad (Andhra Pradesh), India
2. Rutgers University, New Jersey, (USA), Rutgers University, New Jersey, USA
Chapter keywords

Abstract

Pathogenesis of peptic ulcers involves disturbances in the acid-pepsin status of the gastric contents. Neutralization of gastric acid by antacids or inhibition of acid secretion by drugs like H2 receptor blockers, proton pump (H+ K+-ATPase) inhibitors and various other drugs are the main modes of pharmacological treatment of peptic ulcers. Due to the high morbidity associated with this disease, there is a continuous need for newer anti-ulcer drugs.

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